Not one of the Bill of Rights is expendable.

The first enables us to spread news about what the government is trying to do to us.

The second protects the first.

The third prevents the government from planting its enforcers inside our households.

The fourth ensures that the government can't come looking for a reason to prosecute without already having a reasonable hunch of what they can prosecute.  (And the answer to a police officer asking "Can I come in and look around?" is always "Not without a warrant.")

The fifth ensures that we are safe in our person, possessions, documents, and property from a tyrannical government that would otherwise beat confessions out of us all, whether there's anything there to confess or not.

The sixth, seventh, and eighth protect us from a hostile legal system.

The ninth and tenth specifically state that anything not in the Constitution or amendments is forbidden to the federal government, and reserved to the individuals or states.

Each and every one protects us.  Not the government.  Not any given organization.  Each and every individual.

Or, at least, it's supposed to.